In contrast, the Sleeping Beauty injection resulted in 2 lambs (29%) carrying the transgene. So, of all the mammalian systems studies milk emerged as the most efficient system for production and purification of recombinant proteins and biopharmaceuticals, ... PLOS At present, most of the human glycosylated therapeutic proteins are produced from an animal cell culture system. Scaffolds have been developed to replace part or all of the cornea depending on the patient requirements. In this study, we report the germ-line transformation and expression of a cDNA encoding human growth hormone (hGH) in transgenic Drosophila using the Minos transposon. Direct injection of a single spermatozoon into an oocyte (ICSI) can produce apparently normal offspring. Although the production of normal offspring by ICSI has been successful in mice and humans, it has been less successful in many other species. Recently, animal models provided novel insight and significantly improved our understanding of the initiation and perpetuation of human diseases. Because it is more time-consuming and expensive to produce human therapeutic proteins in industrial bioreactors, the demand for the development of transgenic animals as bioreactors is increasing, ... Purifying recombinant proteins from milk has several advantages: milk is easily collectable from lactating animals, tremendous amounts of proteins can be harvested, and milk contains only small amounts of proteases. The latest advances in protein-engineering technologies have allowed drug developers and manufacturers to fine-tune and exploit desirable functional characteristics of proteins of interest while maintaining (and in some cases enhancing) product safety or efficacy or both. Abstract Nonetheless, these results demonstrate that through the direct transduction of the mammary epithelium it is possible to produce potentially toxic proteins in milk, at levels high enough for their purification and biological characterization. Human copper/zinc superoxide dismutase (CuZn-SOD) and extracellular superoxide dismutase (EC-SOD) are two superoxide dismutases that scavenge reactive oxygen species (ROS). This can be overcome by engineering the transgenic bioreactor to express the appropriate modifying enzymes. The mammary gland–specific expression vector BLC14/rhPA was transfected into goat fetal fibroblast cells by electroporation. Although the first recombinant protein produced by transgenic animals is expected to be in the market in 2000, a certain number of technical problems remain to be solved before the various systems are optimized. Tobacco, being a non-food and non-feed plant, has been considered as a good choice for producing enzymes with applications in technical industry, using a transplastomic approach. In practical application, we may express human growth hormone (hGH) (or other pharmaceutical proteins) in swine by using the promoter of epididymis-specific gene Lcn5 (or other promoters) [25,29,39]. The available data indicate that activated eptacog beta exhibits structural (N- and O- glycosylation), pharmacodynamic and pharmacokinetic characteristics similar to activated eptacog alfa, its main competitor, but binds slightly better to platelets and HUVEC, and it is safe and effective.

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