“If you could show that you confer protection to these animals, it would give us a lot of information about protecting humans,” Poeschla said. Glowing cats shed light on Aids. Part of HuffPost Wellness. “We did it to mark cells easily just by looking under the microscope or shining a light on the animal.”. Feline immunodeficiency virus (FIV) causes AIDS in cats as the human immunodeficiency virus (HIV) does in people: by depleting the body's infection-fighting T-cells. In both humans and cats, proteins called restriction factors that normally fight off viral infections are defenseless against HIV and FIV because the viruses evolved potent counter-weapons. Researchers were able to do this by inserting a monkey gene into feline eggs before they were fertilized with sperm. "This provides the unprecedented capability to study the effects of giving Aids-protection genes into an Aids-vulnerable animal," Dr Eric Poeschla of the Mayo Clinic in Rochester, Minnesota, who led the study, said.Poeschla said that besides people, cats and to some extent, chimpanzees, were the only mammals that develop a naturally occurring virus that causes Aids. “It will be interesting to see how enthusiastically this capability in cats is received and adopted by the HIV and neurobiological research communities and what other research opportunities it offers. Register to vote and apply for an absentee ballot today, The essential guide to taking care of your mind and body. As a participant on this forum, it is your responsibility to know and follow our rules. The macaque restriction factor, TRIMCyp, blocks FIV by attacking and disabling the virus's outer shield as it tries to invade a cell. But eventually they plan to expose the cats to the virus and see if they are protected. All rights reserved, Please visit the official Government information portal for Coronavirus by clicking HERE. Please read this message in its entirety. "We haven't shown cats that are AIDS-proof," study researcher Eric Poeschla, a molecular biologist and infectious disease specialist at the Mayo Clinic College of Medicine, told LiveScience. Chicago - US scientists have developed a strain of green-glowing cats with cells that resist infection from a virus that causes feline Aids, a finding that may help prevent the disease in cats and advance Aids research in people. But eventually they plan to expose the cats to the virus and see if they are protected. And these defence proteins are made throughout the cat's body.The team had mated two of the three original green-glowing cats, which produced litters totalling eight kittens which made glowing cells as well.Researchers said the work had several potential uses. But the point is not to breed generations of disease-resistant, glowing cats. BEACON OF HOPE: Modified jellyfish genes make the cats glow. The method worked so well nearly all offspring from the modified eggs have the restriction factor genes. EERIE GLOW: The cat on the right is genetically modified, the cat on the left is not. ©2020 Verizon Media. Election 2020: Jacinda Ardern's absurd day in Christchurch, still battling the wealth tax, Auckland gang members arrested for alleged money laundering linked to China, Warning issued over possible 2.8 tonne space junk collision, Te Teko man not guilty of murder due to insanity, Melbourne homicide: Family of Auckland suspect say they are 'totally shattered', New Zealand cricketing icon John R Reid dies in Auckland, Niwa photographer's award-winning 'lucky break' spotting 50 rare football octopus, Quiz: Afternoon trivia challenge: October 14, 2020, All Blacks vs Australia: John Plumtree fires up over off-the-ball Wallabies tactics, Election 2020: Judith Collins lashes out at 'unemployable' Greens, while discussing her back-up career. Cats and humans have a similar genetic makeup, TODAY reported. Researchers were able to do this by inserting a monkey gene into feline eggs before they were fertilized with sperm. That the protection gene is expressed in the cat lymphoid organs, where AIDS virus spread and cell death mostly play out, is encouraging to us, however.". A Mayo Clinic team has successfully engineered cats to produce a protein that helps their bodies resist the feline immunodeficiency virus (FIV), which causes AIDS in cats. Scientists are making strides in the fight against HIV/AIDS, and the latest involves … glow-in-the-dark cats. A representative non-primate animal model would be a fantastic new tool for studying HIV pathogenesis.”. The scientists also learned that this genetic protection in the cats can be passed on through generations, because the engineered cats had kittens that were also able to produce proteins that protect against virus invasion. Board Rules 1. A Mayo Clinic team has successfully engineered cats to produce a protein that helps their bodies resist the feline immunodeficiency virus (FIV), which causes AIDS in cats. "Cats suffer from this all over the world," he said.Just as the human immunodeficiency virus, or HIV, does in people, FIV works by wiping out infection-fighting T-cells.FIV infected mostly feral cats, of which there are half billion in the world, Poeschla said. It was transmitted by biting, largely by males defending their territory, but companion cats were affected as well.In both humans and cats, proteins called restriction factors that normally fight off viral infections are defenceless against HIV and FIV because the viruses evolved potent counter-weapons. For cats, this may eventually lead to gene therapy or new drug treatments for FIV, he said. The purpose of that experiment was to see if they could successfully perform gene implantation. [Figure][1] CREDIT: MAYO CLINIC Scientists have genetically modified cats by infecting their eggs with a virus containing a foreign gene—the first time this method has worked in a carnivore. All rights reserved. "If you could show that you confer protection to these animals, it would give us a lot of information about protecting humans," Poeschla said.For cats, this may eventually lead to gene therapy or new drug treatments for FIV, he said. In 2008, TODAY reported that Audubon Nature Institute scientists were able to engineer an orange tabby cat to glow fluorescent green in the darkness. The advance could make the cat a valuable new genetic model—and potentially protect it from the feline immunodeficiency virus (FIV). “This technology can be applied to a wide range of species, for many of which there are clear applications and potential benefits,” Dr. Laurence Tiley of the University of Cambridge said in a statement. To do that, they used a harmless virus to insert the genes into the eggs, a process that has already been done in other mammals including mice, pigs, sheep and marmoset monkeys. The team engineered a jellyfish gene into the feline eggs so that they could see if the gene engineering worked -- and it did, as evidenced by the cats' ability to glow in the dark. Of every 100 cats in the United States, between one and three have the virus. The scientists also inserted jellyfish genes that make the modified cells glow an eerie green colour - making the altered genes easy to spot. - Reuters, © 2020 Independent Online and affiliated companies. This isn't the first time a cat has been engineered to glow in the dark. So far, Poeschla's team has only tested cells taken from the animals and found they were resistant to FIV. For the team, which included collaborators in Japan, the trick was to get the monkey gene for the restriction factor - known as TRIMCyp - into cats to block cells from becoming infected with the virus. However, it still remains to be seen if the genetically engineered cats are actually able to resist FIV, though the science is promising, LiveScience reported. FIV infected mostly feral cats, of which there are half billion in the world, Poeschla said. FIV infects mostly feral cats, of which there are half billion in the world, Poeschla said. “Cats suffer from this all over the world,” he said. "The method worked so well nearly all offspring from the modified eggs have the restriction factor genes. FIV infects mostly feral cats, of which there are half billion in the world, Poeschla said. US scientists have developed a strain of green-glowing cats with cells that resist infection from a virus that causes feline Aids, a finding that may help prevent the disease in cats and advance Aids research in people.The study, published yesterday in the journal Nature Methods, involved inserting monkey genes that block the virus into feline eggs, or oocytes, before they are fertilised.The scientists also inserted jellyfish genes that make the modified cells glow an eerie green colour - making the altered genes easy to spot.Tests on cells taken from the cats show they are resistant to feline immunodeficiency virus, or FIV, which causes Aids in cats. To make it easier to check which cells had the monkey gene, the team also inserted a green fluorescent protein gene from the jellyfish Aequorea victoria that makes them glow green. Just as the human immunodeficiency virus, or HIV, does in people, FIV works by wiping out infection-fighting T-cells. Rather, the team plans to study these felines as a new way to develop treatments for HIV and the feline version of the disease. FIV and the human immunodeficiency virus (HIV) are very similar diseases, in that they both deplete the body's own immune cells from fighting off infection. And these defense proteins are made throughout the cat's body. LIGHT OF DAY: An un-modified control cat alongside a genetically modified cat. Researchers said the work has several potential uses. Tests on cells taken from the cats show they are resistant to feline immunodeficiency virus, or FIV, which causes Aids in cats. Poeschla said that besides people, cats and to some extent, chimpanzees, are the only mammals that develop a naturally occurring virus that causes Aids. "We still have to do infection studies involving whole cats. It is transmitted by biting, largely by males defending their territory, but companion cats are affected as well. ... known as feline immunodeficiency virus (FIV) - in these cats.

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