Transgenic Mice 3. An example: Normal mice cannot be infected with polio virus. The giant mouse developed from a fertilized egg transformed with a recombinant DNA molecule containing: the gene for human … Transgenic mice have provided the tools for exploring many biological questions. Theoretically, all living beings can be genetically manipulated. such as: sheep, goats, pigs, cows, rabbits, rats, mice, fish, insects, parasites and even humans have previously been used in this modification process. Transgenic animals are those that have been genetically modified. They lack the cell-surface molecule that, in humans, serves as the receptor for the virus. The examples are: 1. Credit: Ingrid Moen et alet al., BMC Cancer,12/21 (2012), 1-10. Animals. A transgenic animal is one whose genome has been altered by the transfer of a gene or genes from another species or breed. Dolly the sheep was the first mammal to be cloned from an adult cell. Examples of Transgenic Animals. The photo shows two transgenic mice positioned either side of a plain mouse. Following are the examples of transgenic animals: Dolly Sheep. The transgenic mice have been genetically modified so that they carry a green fluorescent protein which glows green under blue light. Cloning Dolly 2. Example. The following points highlight the three important examples of transgenic animal. In this, the udder cells from a 6-year-old Finn Dorset white sheep were injected into an unfertilized egg from a Scottish Blackface ewe, which had its nucleus removed. This image (courtesy of R. L. Brinster and R. E. Hammer) shows a transgenic mouse (right) with a normal littermate (left). So normal mice cannot serve as an inexpensive, easily-manipulated model for studying the disease.
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