The transgenic animals are created because of the benefits they provide to the man. Transgenic Animals. A transgenic animal is one whose genome has been altered by the transfer of a gene or genes from another species or breed. Transgenic mice are developed by injecting DNA into the oocytes or 1-2 celled embryos taken from female mice. such as: sheep, goats, pigs, cows, rabbits, rats, mice, fish, insects, parasites and even humans have previously been used in this modification process. Transgenic animals that produce useful biological products can be created by the introduction of the portion of DNA (or genes) which codes for a particular product such as human protein (a-1-antitrypsin) used to treat emphysema, tissue plasmogen activator (goat), blood clotting factors VIII and IX (sheep) and lactoferrin (cow). After injecting the DNA, the embryo is implanted into the uterus of receptive females. Applications Of Transgenic Animals. Animals. A genetically modified organism (GMO) is an organism whose genetic material has been altered using techniques in genetics, generally known as recombinant DNA technology. Methods for Producing Transgenic Animals: The main principle in the production of transgenic animals is the introduction of a foreign gene or genes into an animal (the inserted genes are called transgenes).The foreign genes must be transmitted through the germ line, so that every cell, including germ cells, of the animal contains the same modified genetic material 18. The photo shows two transgenic mice positioned either side of a plain mouse. Some religious groups might be against the creation of transgenic animals as a violation of the creation, but most should have no problems as long as steps are taken to minimize Following natural gestation and birth, offspring are subject to tissue biopsy and blood sampling: usually ear tissue and blood are screened by polymerase chain reaction and/or Southern analysis for the presence of the transgene. transgenic animals at will, forcing scientists to justify animal use for each experiment. The ability to introduce foreign genes into the germ line and the successful expression of the inserted gene in the organism have allowed the genetic manipulation of animals on an unprecedented scale. Transgenic animals are those that have been genetically modified.. Theoretically, all living beings can be genetically manipulated. Transgenic animals for the production of therapeutic and diagnostic proteins are produced by transferring fertilized, transgene-carrying embryos to recipient animals. Recombinant DNA technology is the ability to combine DNA molecules from different sources into the one molecule. Using DNA Technology to Produce Transgenic Animals Sherry Fuller-Espie, Ph.D., DIC Associate Professor, Cabrini College © Sherry Fuller-Espie, 2003 Transgenic animals Definition.

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