Presented by:- The opportunity to modify the mouse genome by trans-genic technology makes it possible to study loss of function or gain of function of particular mouse genes homologues to specific human genes. In essence, the pharmaceutical industry is asked to develop novel breakthrough medicines to a low cost. There are several advantages with transgenic technology (eg specificity, useful to target most [all?] The miniaturisation of methods for analysis of cardiovascular parameters such as blood pressure, ECG and blood flow has advanced enormously in the last five to seven years. If you continue browsing the site, you agree to the use of cookies on this website. We use cookies to help provide and enhance our service and tailor content and ads. 3(2): p. 114-23. This article presents the rationale for including comparative phenotypic information obtained from transgenic gene knockouts as an integral part of any future therapeutic target selection strategy. Historically, the main utility has been during the target validation phase, ie increasing the possibility that a specific target is a safe and efficient drug target. Approximately 99% of the genes in mouse have homologues genes in man and vice versa. The development of molecular biological tools for mutant-mouse production signaled the new era of contemporary mammalian genetics. Looks like you’ve clipped this slide to already. See our Privacy Policy and User Agreement for details. The main utility of transgenic animals during target validation phase, i.e. Sitemap. ROLE OF TARGET IDENTIFICATION AND TARGET We are always looking for ways to improve customer experience on Elsevier.com. 3 Waterston, RH et al. Your review was sent successfully and is now waiting for our team to publish it. Ideally, this analysis should be done before the company invests too large resources to generate an optimised small chemical entity. Transgenic animals can be used broadly in the discovery of new medicines. It is clear that genetically modified mice have many characteristics making them useful to understand novel disease mechanisms and to find new pharmaceutical treatment paradigms. Nature, 2002. The blood volume of a mouse is very small and therefore the sample size that can be collected is small. Cookie Notice
It is a challenging task to understand if a specific compound is acting only through the target it is aimed at. 9 Carmeliet, P, Moons, L and Collen, D. Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis. This is challenging in many areas but the progress has been tremendously fast in the last five to 10 years. III PHARMACOLOGY OF ORALLY BIOAVAILABLE GP IIb/IIIa ANTAGONISTS, V LACK OF EXPLANATION FOR EXCESS MORTALITY IN LARGE PHASE III TRIALS. This review will mainly focus on how transgenic systems can help to deliver drug targets that can open up completely new treatment opportunities and also how the technology can help maximise the quality of new chemical compounds. Can also include students and academics in the related areas of study. In-depth analysis of targets will help to link specific genes to disease and thereby discover truly novel therapeutic approaches. Historically, the main utility has been during the target validation phase, ie increasing the possibility that a specific target is a safe and efficient drug target. By using our website you accept our use of cookies. 1) Human and mouse have to be similar on the genetic level to allow for identification of homologues genes and pathways/networks.
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