Tumors were completely eradicated following 3 separate injections in the host without weight loss. Prior treatment with any drug or construct that targets BCMA on tumor cells (eg, other bispecific antibody constructs, antibody drug conjugates, or CAR-T cells), other than Group C where prior treatment with GSK2857916 (belantamab mafodotin) is required. A Study to Assess AMG 701 Montherapy, or in Combination With Pomalidomide, With or Without, Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, Supportive & Palliative Care Editorial Board, Levels of Evidence: Supportive & Palliative Care, Levels of Evidence: Screening & Prevention, Levels of Evidence: Integrative Therapies, U.S. Department of Health and Human Services. Females planning to become pregnant while on study through 75 days after receiving the last dose of AMG 701 or 28 days after the last dose pomalidomide or dexamethasone, whichever occurs later. AMG 701 induced lysis of autologous patient MM cells from relapse and refractory patients. Blood 2019; 134 (Supplement_1): 135. doi: https://doi.org/10.1182/blood-2019-128528. The clinical trials on this list are studying Anti-BCMA/CD3 BiTE Antibody AMG 701. Defined as time from start of treatment until disease progression or death. Please remove one or more studies before adding more. Firstly, AMG 701 induced specific and efficacious T cell-dependent cytotoxicity (TDCC) against all MM cell lines tested, regardless of sensitivity to current anti-MM agents and expression levels of BCMA. Age ≥ 18 years at the time of signing the informed consent. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Here, we confirmed AMG 701-mediated T cell-redirected lysis of MM cells, defined immunomodulatory effects of AMG 701, and investigated combination potential of AMG 701 with immunomodulatory drugs (IMiDs) in human MM. Highly effective methods of birth control include sexual abstinence (males, females); vasectomy; bilateral tubal ligation/occlusion; or a condom with spermicide (males) in combination with hormonal birth control or intrauterine device (IUD) (females). Unsubscription is always possible via email. History of serious hypersensitivity associated with thalidomide, pomalidomide, or lenalidomide (> grade 3). Observational study — observes people and measures outcomes without affecting results. The number of times you access AdisInsight, the number of searches you performed, and the number of profiles you viewed will be provided to your organization both in aggregate with other users and individually by your email address. Multiple myeloma meeting the following criteria: Pathologically-documented diagnosis of multiple myeloma that is relapsed or is refractory as defined by the following: Relapsed after ≥ 2 lines of prior therapy that must include a proteasome inhibitor (PI), an immunomodulatory drug (IMiD), and, where approved and available, a CD38-directed cytolytic antibody in any order during the course of treatment OR refractory to PI, IMiD and CD38-directed cytolytic antibody; Subjects who could not tolerate a PI, IMiDs, or a CD38-directed cytolytic antibody are eligible to enroll in the study. Your email address will not be shared without your permission. Combination of AMG 701 and len significantly induced superior MM cell regression, compared to either monotherapy, resulting in enhanced tumor regression and prevention of disease relapse. Subjects must have received ≥ 2 lines of prior therapy that must inclue a proteasome inhibitor (PI), lenalidomide, and where approved and available a CD38-directed antibody. Anderson:Sanofi-Aventis: Other: Advisory Board; Bristol-Myers Squibb: Other: Scientific Founder; Oncopep: Other: Scientific Founder; Amgen: Consultancy, Speakers Bureau; Janssen: Consultancy, Speakers Bureau; Takeda: Consultancy, Speakers Bureau; Celgene: Consultancy, Speakers Bureau. Call us at (888) 828-2206. Detectable hepatitis B virus DNA suggests occult hepatitis B; Positive Hepatitis C virus antibody (HepCAb): hepatitis C virus RNA by PCR is necessary. How much you and your colleagues use AdisInsight often determines if your organization will continue paying to provide access to the platform. International patient clinical studies questions. Defined as time from start of treatment until death due to any cause. The purpose of this study is to determine (during the escalation portion) if AMG 701 given as weekly short term IV infusions is safe and tolerable followed by a dose expansion part to gain further efficacy and safety experience with AMG 701 in adult subjects with relapsed / refractory multiple myeloma. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Human genetic validation is used whenever possible to strengthen the evidence base for as many of our programs as possible. allow you to toggle between having all search items start with or contain the text

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