"There are a limited number of products approved to treat bipolar depression and even fewer products that have been studied and approved to treat the full spectrum of bipolar disorder, from mania through depression. Cision Distribution 888-776-0942 Exicure will also be eligible to receive tiered royalties on worldwide net product sales of mid-single digit to mid-teens percentages on worldwide net product sales. Editas Medicine Forward-Looking StatementsThis press release contains forward-looking statements and information within the meaning of The Private Securities Litigation Reform Act of 1995. International Communications & Public Relations. Allergan Forward-Looking Statements Statements contained in this press release that refer to future events or other non-historical facts are forward-looking statements that reflect Allergan’s current perspective on existing trends and information as of the date of this release. The agreement covers a range of first-in-class ocular programs targeting serious, vision-threatening diseases based on Editas Medicine’s unparalleled CRISPR genome editing platform, including CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a). For the latest information and scientific presentations, please visit www.editasmedicine.com. Kerry Conlin The BRILLIANCE clinical trial is a Phase 1/2 study to evaluate AGN-151587 for the treatment of patients diagnosed with LCA10 and is the world’s first human study of an in vivo, or inside the body, CRISPR genome editing medicine. If you consent, choose “I accept.” You can withdraw your consent by changing your browser settings to erase cookies from your computer’s hard drive, block all cookies, or receive a warning before a cookie is stored. Cariprazine shows lower binding affinity to the serotonin 5-HT2C and α1A- adrenergic receptors and has no appreciable affinity for cholinergic muscarinic receptors. We look forward to sharing future updates from this clinical trial and our ocular program.”. About Leber Congenital AmaurosisLeber congenital amaurosis, or LCA, is a group of inherited retinal degenerative disorders caused by mutations in at least 18 different genes. Please turn on JavaScript and try again. | Statements contained in this press release that refer to future events or other non-historical facts are forward-looking statements that reflect Allergan's current perspective on existing trends and information as of the date of this release. Allergan and Richter Announce Positive Topline Results from Phase III Study of Cariprazine for the Treatment of Bipolar I Depression, Privacy Notice for Adverse Event Reporting. For years, Allergan has had an unwavering commitment to advancing eye care treatments. Exicure believes that its proprietary SNA architecture has distinct chemical and biological properties that may provide advantages over other nucleic acid therapeutics and may have therapeutic potential to target diseases not typically addressed with other nucleic acid therapeutics. Allergan's success is powered by our more than 18,000 global colleagues' commitment to being Bold for Life. Unless otherwise specified, all product names appearing in this Internet site are trademarks owned by or licensed to AbbVie Inc., its subsidiaries or affiliates. Terms of use. AGN-151587 (EDIT-101) is the first in vivo CRISPR medicine to be administered to patients, Additional patient enrollment to the BRILLIANCE Clinical Trial is ongoing. Forward-Looking Statement . Filter By Year: 2020 2019 2018. RGH-MD-54 is a phase III, randomized, double-blind, placebo-controlled, parallel-group, multicenter, fixed-dose clinical trial in patients with bipolar I depression. One of the most common hair loss disorders and a subject of the collaboration is androgenetic alopecia also known as pattern baldness, affecting approximately 50 million men and 30 million women in the United States. AGN-151587 is administered via a subretinal injection to deliver the gene editing machinery directly to photoreceptor cells. not for release, publication or distribution, in whole or in part, in, into or from any jurisdiction where to do so would constitute a violation of the relevant laws or regulations of such jurisdiction this announcement is being made … It also helps deliver content-specific information to you and tracks how sections of websites are used. Cariprazine demonstrated up to ~8-fold greater in vitro affinity for dopamine D3 vs D2 receptors. To participate in the conference call, please dial 866-997-1948 or 270-215-9856 five minutes prior to start time. - Exicure to Receive $25 Million Upfront Payment and Up to $725 Million in potential Milestones, - Exicure to Host Conference Call Today at 8:30am ET/7:30am CT. CHICAGO & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Exicure, Inc., (NASDAQ:XCUR) a pioneer in gene regulatory and immunotherapeutic drugs utilizing spherical nucleic acid (SNA™) technology, today announced that Allergan’s wholly-owned subsidiary, Allergan Pharmaceuticals International Limited, and Exicure, Inc. have entered into a global collaboration agreement to discover and develop novel treatments for hair loss disorders based on Exicure’s proprietary SNA technology. As part of its approach to delivering innovation for better patient care, Allergan has built one of the broadest pharmaceutical and device research and development pipelines in the industry. Your consent is voluntary; however, if you do not consent to cookies being installed on your browser, Allergan may not be able to provide you full access to or all the functionality of our websites. View our social media channel guidelines », AbbVie.com For more information, visit Allergan's website at www.Allergan.com. The information in the press releases on these pages was factually accurate on the date of publication. For more information, visit Allergan's website at www.Allergan.com. ksharma@macbiocom.com. Having another product proven to treat the full range of bipolar disorder would be a welcome addition to the treatment options currently available to the psychiatry community and patients." This is the second positive pivotal trial Under the terms of the agreement, Allergan is responsible for development and commercialization of optioned products, subject to Editas Medicine’s option to co-develop and share equally in the profits and losses of two optioned products in the United States. As part of its approach to delivering innovation for better patient care, Allergan has built one of the broadest pharmaceutical and device research and development pipelines in the industry. Allergan markets a portfolio of leading brands and best-in-class products primarily focused on four key therapeutic areas including medical aesthetics, eye care, central nervous system and gastroenterology. By selecting "I accept," I authorize Allergan, or any contracted third parties acting on its behalf, to install cookies on my browser to remember the information that I input, track how I use sections of websites, enable Allergan to remember my user custom preferences, and to tailor my access to the website per my preferences. Allergan is an industry leader in Open Science, a model of research and development, which defines our approach to identifying and developing game-changing ideas and innovation for better patient care. Except as expressly required by law, Allergan disclaims any intent or obligation to update these forward-looking statements. Forward-looking statements in this press release include statements regarding the Companies’ plans with respect to the Phase 1/2 clinical trial for AGN-151587 (EDIT-101). A, HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American. 212-362-1200 The company plans to submit a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration in 2nd half of 2018. Except as expressly required by law, Allergan disclaims any intent or obligation to update these forward-looking statements. Your consent is required for Allergan to remember your user details and preferences over time. Exicure, Inc. is a clinical-stage biotechnology company developing therapeutics for immuno-oncology, inflammatory diseases and genetic disorders based on our proprietary Spherical Nucleic Acid, or SNA technology. Additional details are available on www.clinicaltrials.gov (NCT#03872479). This area is reserved for members of the news media. These factors include, among others, the difficulty of predicting the timing or outcome of FDA approvals or actions, if any; the impact of competitive products and pricing; market acceptance of and continued demand for Allergan’s products; the impact of uncertainty around timing of generic entry related to key products, including RESTASIS®, on our financial results; risks associated with divestitures, acquisitions, mergers and joint ventures; risks related to impairments; uncertainty associated with financial projections, projected cost reductions, projected debt reduction, projected synergies, restructurings, increased costs, and adverse tax consequences; difficulties or delays in manufacturing; and other risks and uncertainties detailed in Allergan’s periodic public filings with the Securities and Exchange Commission, including but not limited to Allergan's Annual Report on Form 10-K for the year ended December 31, 2019. Patients will receive a single administration of AGN-151587 via subretinal injection in one eye. MacDougall 781-235-3060 Allergan Press Releases. AbbVie to Acquire Allergan in Transformative Move for Both Companies. of cariprazine for this investigational use. With its widely acknowledged steroid chemistry expertise, Richter is a significant player in the Women's healthcare field worldwide. Exicure's lead program is in a Phase 1b/2 trial in patients with advanced solid tumors. This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Allergan Forward-Looking Statements Statements contained in this press release that refer to future events or other non-historical facts are forward-looking statements that reflect Allergan's current perspective of existing trends and information as of the date of this release. DUBLIN, Jan. 31, 2020 /PRNewswire/ -- Allergan plc (NYSE: AGN) today announced it will release fourth quarter and full year 2019 financial results on Monday, February 10, 2020, prior to the open of U.S. financial markets. Exicure is based outside of Chicago, IL and in Cambridge, MA. About Allergan plcAllergan plc (NYSE: AGN), headquartered in Dublin, Ireland, is a global pharmaceutical leader focused on developing, manufacturing and commercializing branded pharmaceutical, device, biologic, surgical and regenerative medicine products for patients around the world.

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